Clinical phenotype, NOD2 genotypes, and treatment observations in Yao syndrome: a retrospective case series
Our findings substantiate the occurrence of fevers, arthralgia/arthritis, rash, chronic gastrointestinal symptoms, and sicca-like symptoms described previously in patients with YAOS. Novel clinical features and one <i>NOD2</i> variant not previously described were identified. Glucocorticoids, biologic IL-1 inhibitors, and IL-6 receptor inhibitors appeared to be effective for treatment of patients with YAOS.
Authors
- Katrina Ann Williamson (ORCID: https://orcid.org/0000-0002-6589-9219)
- Matthew J. Samec (ORCID: https://orcid.org/0000-0002-4736-6582)
- Ann M. Moyer (ORCID: https://orcid.org/0000-0003-2590-7218)
- Edward V. Loftus (ORCID: https://orcid.org/0000-0001-7199-6851)
- John M. Davis (ORCID: https://orcid.org/0000-0002-9710-8143)
- Afsáneh Alavi (ORCID: https://orcid.org/0000-0003-1171-4917)
- Amir B. Orandi (ORCID: https://orcid.org/0000-0002-3720-2402)
- Cynthia S. Crowson (ORCID: https://orcid.org/0000-0001-5847-7475)
- Benjamin Wang (ORCID: https://orcid.org/0000-0001-8691-9410)
- Jenny A Patel
Institutions
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-04
- DOI
- https://doi.org/10.3389/fimmu.2024.1304792
- Citations
- 10
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.34