Impaired Mycobacterium tuberculosis-specific T-cell memory phenotypes and functional profiles among adults with type 2 diabetes mellitus in Uganda
Type 2 DM impairs the memory phenotypes and functional profiles of <i>Mtb</i>-specific CD4<sup>+</sup> and CD8<sup>+</sup> T cells, potentially indicating underlying immunopathology towards increased active TB disease risk.
Authors
- Andrew Peter Kyazze (ORCID: https://orcid.org/0000-0002-9002-4510)
- Bernard S. Bagaya (ORCID: https://orcid.org/0000-0002-3847-2615)
- Reinout van Crevel
- Davis Kibirige (ORCID: https://orcid.org/0000-0001-5127-3031)
- David Patrick Kateete (ORCID: https://orcid.org/0000-0001-8075-3069)
- Stephen Cose (ORCID: https://orcid.org/0000-0002-5156-037X)
- Obondo James Sande (ORCID: https://orcid.org/0000-0002-2301-5980)
- Phillip Ssekamatte (ORCID: https://orcid.org/0000-0002-3418-8414)
- Irene Andia Biraro (ORCID: https://orcid.org/0000-0002-8303-6046)
- Marjorie Nakibuule
- Rose Nabatanzi (ORCID: https://orcid.org/0000-0002-7033-2241)
- Diana Sitenda (ORCID: https://orcid.org/0000-0001-8169-2819)
Institutions
- Radboud University Nijmegen (NL)
- Rubaga Hospital (UG)
- Radboud University Medical Center (NL)
- Makerere University (UG)
- Uganda Virus Research Institute (UG)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-04
- DOI
- https://doi.org/10.3389/fimmu.2024.1480739
- Citations
- 7
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Medical Research Council