Effect of older age and/or ACL injury on the dose–response relationship between ambulatory load magnitude and immediate load-induced change in serum cartilage oligomeric matrix protein
Age but not prior ACL injury influences resting sCOMP and load-induced sCOMP. The dose-response relationship between ambulatory load magnitude and load-induced sCOMP changes is not affected by age, ACL injury, or sex. A better understanding of systemic sCOMP and the role of its mechanoresponse for the understanding of osteoarthritis pathophysiology and monitoring intervention efficacy may require knowledge of individual cartilage composition and tissue-level loading parameters.
Authors
- Anna‐Maria Liphardt (ORCID: https://orcid.org/0000-0003-0739-1959)
- Simon Herger (ORCID: https://orcid.org/0000-0001-5207-2100)
- Annegret Mündermann (ORCID: https://orcid.org/0000-0002-6472-1689)
- Corina Nüesch (ORCID: https://orcid.org/0000-0002-7526-9536)
- Christian Egloff (ORCID: https://orcid.org/0000-0001-6867-0527)
Institutions
- University Hospital of Basel (CH)
- Universitätsklinikum Erlangen (DE)
Publication Details
- Journal
- Journal of sport and health science/Journal of Sport and Health Science
- Published
- 2024-10-04
- DOI
- https://doi.org/10.1016/j.jshs.2024.100993
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung