Rapid Reversal of Pulmonary Hypertension by High-Dose Thiamine Supplementation: A Case Report
Pulmonary hypertension (PH) is characterized by progressive right heart failure and a poor prognosis.A 50-year-old man with schizophrenia and poor nutrition status presented with palpitations, dyspnea at rest, and shock.Right heart catheterization demonstrated an elevated mean pulmonary arterial pressure (PAP) of 40 mm Hg and normal pulmonary artery wedge pressure, indicating precapillary PH.Despite the initiation of catecholamines and diuretics, the patient's condition remained refractory, and shock persisted.Subsequent thiamine supplementation resulted in a rapid reduction of PAP, to 17 mm Hg.Prompt recognition of thiamine deficiency in precapillary PH is essential to prevent a fatal outcome.
Authors
- Masaki Ieda (ORCID: https://orcid.org/0000-0003-4724-3299)
- Yoshiki Shinya (ORCID: https://orcid.org/0000-0002-6595-3713)
- Shun Kohsaka (ORCID: https://orcid.org/0000-0003-3779-2972)
- Yoshikazu Kishino (ORCID: https://orcid.org/0000-0003-3291-2795)
- Mizuki Momoi (ORCID: https://orcid.org/0000-0003-0048-5258)
- Keisuke Matsumura (ORCID: https://orcid.org/0000-0001-6756-7544)
- Takahiro Hiraide (ORCID: https://orcid.org/0000-0002-8324-0004)
- Yasuyuki Shiraishi (ORCID: https://orcid.org/0000-0002-5036-3593)
- Wataru Iai
- T. Moriizumi
Institutions
- Keio University Hospital (JP)
- National Hospital Organization (JP)
- National Hospital Organization Saitama Hospital
Publication Details
- Journal
- CJC Open
- Published
- 2024-10-04
- DOI
- https://doi.org/10.1016/j.cjco.2024.09.013
- Citations
- 1
- Primary Topic
- Alcoholism and Thiamine Deficiency
- Type
- article
- Field-Weighted Citation Impact
- 0.37
Funders
- Bristol-Myers Squibb
- Pfizer
- Japan Society for the Promotion of Science