High HIV-1 genetic diversity and low prevalence of transmitted drug resistance among treatment-naive people living with HIV in Madagascar
Our results show a low prevalence of ARV resistance mutations among adult treatment-naive PLHIV in Madagascar. In children under 15 years old, 92 % were infants under two years old, the high resistance rate is likely related to mother-to-child transmission. No resistance mutation to dolutegravir was detected. We also observed high frequencies of subtypes C, B, A1 and a high proportion of URFs, highlighting an ongoing dynamic epidemic.
Authors
- Christelle Butel
- Eric Nerrienet
- Danielle Aurore Doll Rakoto (ORCID: https://orcid.org/0009-0005-6946-4676)
- Martine Peeters
- Fetra Angelot Rakotomalala
- Luca Maharavo (ORCID: https://orcid.org/0009-0000-7047-2060)
- Felana Ranaivo Rabetokotany
- Luc Hervé Samison (ORCID: https://orcid.org/0000-0003-0776-1438)
- Éric Delaporte (ORCID: https://orcid.org/0000-0002-1822-9853)
- Ahidjo Ayouba (ORCID: https://orcid.org/0000-0002-5081-1632)
- Nicole Vidal
- Hajanirina Nathanaella Randriamananjara
- Nicolas Fernandez-Nuñez
- Tahinamandranto Rasamoelina (ORCID: https://orcid.org/0000-0002-3223-3277)
- Santatriniaina Hajanirina Dauphin Randriarimanana
- Laetitia Serrano
- François-Xavier Babin
Institutions
- University of Antananarivo (MG)
- Inserm (FR)
- Fondation Mérieux (FR)
- Institut de Recherche pour le Développement (BO)
- Institut de Recherche pour le Développement (FR)
Publication Details
- Journal
- Infection Genetics and Evolution
- Published
- 2024-10-04
- DOI
- https://doi.org/10.1016/j.meegid.2024.105679
- Citations
- 2
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.78