Safety and efficacy of praziquantel in pregnant women infected with Schistosoma haematobium in Lambaréné, Gabon – Clinical results from the randomized, single-blinded, controlled freeBILy-Gabon trial
This first randomized controlled trial investigating PZQ in pregnant women with S. haematobium found PZQ to be safe, effective, and reducing maternal anemia. We recommend treating confirmed infections to prevent morbidity in pregnant women.
Authors
- Bayodé Roméo Adégbitè (ORCID: https://orcid.org/0000-0003-4208-6212)
- Paul L. A. M. Corstjens (ORCID: https://orcid.org/0000-0002-0004-0526)
- Jean-Claude Dejon-Agobé
- Jacob Gerstenberg (ORCID: https://orcid.org/0009-0008-1604-9710)
- Andrea Kreidenweiss (ORCID: https://orcid.org/0000-0002-5025-7221)
- Govert J. van Dam (ORCID: https://orcid.org/0000-0003-3773-0819)
- Pytsje T. Hoekstra (ORCID: https://orcid.org/0000-0002-7285-9223)
- Moustapha Nzamba Maloum (ORCID: https://orcid.org/0000-0001-8213-8465)
- Mario Recker (ORCID: https://orcid.org/0000-0001-9489-1315)
- Jean‐Ronald Edoa
- Jeannot Fréjus Zinsou (ORCID: https://orcid.org/0000-0003-4719-8299)
- Paul Alvyn Nguema Moure (ORCID: https://orcid.org/0000-0002-9703-4893)
- Brice Meulah (ORCID: https://orcid.org/0000-0003-2068-1563)
- Romuald Beh (ORCID: https://orcid.org/0000-0001-9006-5550)
- Yabo Josiane Honkpéhèdji (ORCID: https://orcid.org/0000-0002-9726-6643)
- Bertrand Lell (ORCID: https://orcid.org/0000-0003-1427-3002)
- Saïdou Mahmoudou (ORCID: https://orcid.org/0009-0007-6476-4068)
- Michael Ramharter
- Romeo Laclong Lontchi
- Peter G Kremsner
- Ayôla Akim Adégnika (ORCID: https://orcid.org/0000-0003-3197-5946)
- Selidji T Agnandji
Institutions
- Universität Hamburg (DE)
- University of Exeter (GB)
- Leiden University Medical Center (NL)
- Centre de Recherche Médicales de Lambaréné (GA)
- University Medical Center Hamburg-Eppendorf (DE)
- German Center for Infection Research (DE)
- Bernhard Nocht Institute for Tropical Medicine (DE)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2024-10-04
- DOI
- https://doi.org/10.1016/j.ijid.2024.107253
- Citations
- 4
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- European and Developing Countries Clinical Trials Partnership