Deer antler stem cells immortalization by modulation of hTERT and the small extracellular vesicles characters
We successfully isolated primary stem cells from deer antler and established the immortalized hTERT-AnSCs. Remarkably, this cell line maintains its stem cell characteristics even after 40 passages. The sEVs derived from these cells exhibit identical morphological and structural features to those of primary AnSCs. This research provides essential technical support for the application of AnSCs and their sEVs in regenerative medicine.
Authors
- Ze Chen (ORCID: https://orcid.org/0009-0002-1637-2864)
- Yinghua Peng (ORCID: https://orcid.org/0000-0003-0835-8317)
- Jun Song (ORCID: https://orcid.org/0000-0002-6128-6378)
- Yuying Li (ORCID: https://orcid.org/0000-0003-0165-8018)
- Deshuang Meng
- Jia Guo (ORCID: https://orcid.org/0000-0002-4055-9103)
- Xin Pang
Institutions
- Chinese Academy of Agricultural Sciences (CN)
- Dongfeng Motor Group (China) (CN)
- Institute of Special Animal and Plant Sciences (CN)
- Changchun University of Technology (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2024-10-04
- DOI
- https://doi.org/10.3389/fvets.2024.1440855
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- People's Government of Jilin Province
- Tsinghua University
- Chinese Academy of Agricultural Sciences
- Agricultural Science and Technology Innovation Program