Association of lipid-lowering drugs with the risk of type 2 diabetes and its complications: a mendelian randomized study
This Mendelian randomization study suggests an association between HMGCR and the pathogenesis of type 2 diabetes mellitus, with increased genetically proxied HMGCR expression reducing the risk of type 2 diabetes mellitus, while PCSK9 and NPC1L1 show no significant association with type 2 diabetes mellitus. These findings may offer more reasonable lipid-lowering drug options for patients with dyslipidemia.
Authors
- Yue‐Yang Zhang
- Bingxue Chen (ORCID: https://orcid.org/0000-0002-3367-6555)
- Qin Wan (ORCID: https://orcid.org/0000-0001-7765-1416)
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- First Affiliated Hospital of Sichuan Medical University (CN)
- Shanghai Clinical Research Center (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2024-10-04
- DOI
- https://doi.org/10.1186/s13098-024-01477-8
- Citations
- 3
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Ministry of Science and Technology of the People's Republic of China