Surrogate Immunohistochemical Markers of Proliferation and Embryonic Stem Cells in Distinguishing Ameloblastoma from Ameloblastic Carcinoma
Ki-67 IHC as a proliferation marker, particularly when assessed via automated methods, was helpful in distinguishing AC from AB cases. In contrast to other studies, surrogate IHC markers of embryonic stem cells, SOX2, OCT4 and GPC-3, were unreliable in distinguishing the two entities.
Authors
- Melvin Ambele (ORCID: https://orcid.org/0000-0002-6636-2026)
- Willie F. P. van Heerden (ORCID: https://orcid.org/0000-0003-2494-667X)
- Chané Smit (ORCID: https://orcid.org/0000-0003-4047-6356)
- Johan Opperman (ORCID: https://orcid.org/0000-0002-9684-6670)
- Liam Robinson (ORCID: https://orcid.org/0000-0002-0549-7824)
- Amir Afrogheh (ORCID: https://orcid.org/0000-0001-5818-7945)
- Marlene B. van Heerden (ORCID: https://orcid.org/0000-0002-3710-8352)
- Haroon Moolla (ORCID: https://orcid.org/0000-0001-7027-6297)
Institutions
- South African Medical Research Council (ZA)
- Western Cape Department of Health (ZA)
- University of Cape Town (ZA)
- Stellenbosch University (ZA)
- Steve Biko Hospital (ZA)
- Netcare Unitas Hospital (ZA)
- University of Pretoria (ZA)
- University of the Western Cape (ZA)
Publication Details
- Journal
- Head and Neck Pathology
- Published
- 2024-10-04
- DOI
- https://doi.org/10.1007/s12105-024-01704-8
- Citations
- 3
- Primary Topic
- Oral and Maxillofacial Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- University of Pretoria