Feasibility and Safety of Targeting Mitochondria Function and Metabolism in Acute Myeloid Leukemia
In this review, we present an overview of the most recent studies targeting mitochondrial metabolism in AML. We highlight that targeting of the specific energy metabolism dependencies of AML blasts provides an opportunity to achieve long-term responses with a reasonable safety profile. We emphasize that currently used drugs and their combinations display dose-limiting toxicities or are not efficient enough to completely eradicate leukemic stem cells. Thus, further studies of complex metabolic rewiring of leukemia cells before and after combinatorial therapies are warranted.
Authors
- Marina Konopleva (ORCID: https://orcid.org/0000-0002-9347-2212)
- Natalia Baran (ORCID: https://orcid.org/0000-0003-0618-4798)
- Monika Chomczyk
- Patryk Firmanty (ORCID: https://orcid.org/0009-0004-2345-4627)
- Shubhankar Dash
Institutions
- Albert Einstein College of Medicine (US)
- The University of Texas MD Anderson Cancer Center (US)
- Instytut Hematologii i Transfuzjologi (PL)
Publication Details
- Journal
- Current Pharmacology Reports
- Published
- 2024-10-04
- DOI
- https://doi.org/10.1007/s40495-024-00378-8
- Citations
- 2
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Narodowe Centrum Nauki
- Narodowym Centrum Nauki
- National Institutes of Health
- University of Texas MD Anderson Cancer Center
- National Cancer Institute