Visible‐Light Photoredox‐Catalyzed Trifunctionalization of Unactivated Alkenes via Diamidation and Cyano Migration

Abstract A visible‐light‐promoted, nitrogen‐centered radical‐initiated trifunctionalization of 5‐hexenonitriles via diamidation and 1,4‐cyano migration, using 1 mol% fac ‐Ir(ppy) 3 as the photoredox catalyst, is reported. In this protocol, the O ‐acylhydroxylamine derivative acts as a bifunctional reagent, and the carbonitrile solvent also participates in the reaction. This transformation proceeds at room temperature, yielding a wide range of functionalized β‐amino nitriles, including the derivatives of natural products and pharmaceuticals.