Rosmarinic acid promotes cartilage regeneration through Sox9 induction via NF-κB pathway inhibition in mouse osteoarthritis progression
RosA attenuated the OA progression by suppressing the catabolic factors expression. These effects were facilitated through the suppression of the NF-κB signaling pathway. Additionally, it promotes cartilage regeneration by inducing anabolic factors. Therefore, RosA shows potential as an effective therapeutic agent for treating OA.
Authors
- Ji‐Ae Hong (ORCID: https://orcid.org/0000-0003-1323-1505)
- Jong-Young Kwak (ORCID: https://orcid.org/0000-0003-4393-5140)
- Cho-Long Kim (ORCID: https://orcid.org/0009-0006-4594-3338)
- Li‐Jung Kang (ORCID: https://orcid.org/0000-0002-0092-1083)
- Jung‐Soon Mo (ORCID: https://orcid.org/0000-0001-9462-329X)
- Ye Eun Sim
- Dong Hyun Kim (ORCID: https://orcid.org/0000-0002-9211-208X)
- In-Jeong Lee
Institutions
- Jeonnam Bioindustry Foundation (KR)
- Ajou University (KR)
Publication Details
- Journal
- Heliyon
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38936
- Citations
- 6
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.82
Funders
- National Research Foundation
- Ajou University
- Korea Basic Science Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea