Relation of <i>JAK2</i> V617F allele burden and coronary calcium score in patients with essential thrombocythemia
The average <i>JAK2</i> allele burden decreased in our patients with high-risk ET during the four-year period. However, in the small subgroup whose <i>JAK2</i> mutation burden increased the Agatston coronary calcium score increased as well. This finding, which should be interpreted with caution and validated in a larger group, is in line with emerging evidence that <i>JAK2</i> mutation accelerates atherosclerosis and can be regarded as a non-classical risk factor for cardiovascular disease.
Authors
- Tadej Pajič (ORCID: https://orcid.org/0000-0002-6535-0357)
- Ajda Anžič Drofenik
- Mojca Božič Mijovski (ORCID: https://orcid.org/0000-0003-1879-6353)
- Aleš Blinc (ORCID: https://orcid.org/0000-0002-7538-1595)
- Matjaž Sever (ORCID: https://orcid.org/0000-0002-9487-5451)
- Matjaž Vrtovec
Institutions
- University of Ljubljana (SI)
- Ljubljana University Medical Centre (SI)
- University of Maribor (SI)
Publication Details
- Journal
- Radiology and Oncology
- Published
- 2024-10-04
- DOI
- https://doi.org/10.2478/raon-2024-0036
- Citations
- 2
- Primary Topic
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.88
Funders
- Javna Agencija za Raziskovalno Dejavnost RS