Comprehensive analysis of a-and b-thalassemia genotypes and hematologic phenotypes
The clinical phenotype of thalassemia is influenced by molecular mechanism, and the two kinds of thalassemia can interact with each other. The clinical severity is positively correlated with the imbalance of a peptide chain and b peptide chain. A comprehensive understanding of the hematologic phenotype differences between different genotypes and subtypes of thalassemia can provide more accurate data for genetic counseling of thalassemia.
Authors
- Huang Shengwen
- Hai Huang (ORCID: https://orcid.org/0000-0003-2693-6993)
- Heng Wang (ORCID: https://orcid.org/0000-0002-3563-2337)
- Dan Xie (ORCID: https://orcid.org/0000-0003-3173-3920)
- Chen Yaping
- AN Bang-quan
Institutions
- Guiyang Medical University (CN)
- Guizhou University (CN)
- The First People's Hospital of Guiyang (CN)
- Guizhou Provincial People's Hospital (CN)
Publication Details
- Journal
- Journal of Medical Biochemistry
- Published
- 2024-10-04
- DOI
- https://doi.org/10.5937/jomb0-51740
- Citations
- 2
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.88
Funders
- National Natural Science Foundation of China