Status of Vit D in Ambulatory Consulting Patients in the City of Meknes

Introduction: Vitamin D (vit D) is both a vitamin and a hormone whose needs are covered by skin photosynthesis (UVB) and secondarily by diet. It plays an important role in the regulation of phosphocalcic homeostasis. Insufficiency in this vitamin exposes to several bone and extra-bone adverse effects. The objectives of this work are to evaluate the status of vit D in ambulatory consulting patients at the Meknes HMMI and to establish correlations between the 25OHD rate and demographic, clinical and biological parameters. Materials and Methods: This is a prospective monocentric observational study carried out over a 4-month period from February 1 to May 4, 2017 of 300 patients (274 female, 26 male) who are ambulatory consultants with a prescription for Vit D dosage. All patients completed a questionnaire and received an electrochemiluminescence (ECLIA) 25OHD assay using the Roche Diagnostics Cobas® 6000 analyzer. The normal rate is defined by [Vit D] > 30ng/ml, hypovitaminosis by [Vit D] < 30ng/ml. Patients also benefited from an assay for calcium, phosphoremia, intact PTH and other parameters. Results: The average age of our patients was 51.75±12.95 years with a sex ratio M/F of 0.01. Hypovitaminosis is found in 91.3% of our population. Indeed, 29.3% of patients suffered from moderate vit D deficiency, 17.3% from severe deficiency, 44.7% from vit D deficiency. Hypovitaminosis D is positively and significantly correlated with sex, BMI, veil, sunscreen use, muscle pain, fractures and vit D treatment. On the contrary, it is not correlated with age, phototype, asthenia, bone pain and high blood pressure. Concerning the relationship between hypovitaminosis and the biological parameters studied: hypovitaminosis is associated in 95.3% (p=0.191 r=0.212) of cases with normocalcemia, in 95% of cases with normophosphatemia (p=0.09 r=0.183) in 94% (p=1 r=1) of cases with hyperparathyroidism, in 97.7% of cases to thyroid disorders (p=0.331 r=0.331) and in 94.4% to diabetes ......