Preparation and In Vitro Evaluation of Ranitidine Floating Microspheres in The Treatment of Gastrointestinal Infections

Introduction: Ranitidine hydrochloride, a member of the H2-receptor antagonist class, is widely employed in treating gastrointestinal conditions like ulcers, gastroesophageal reflux disease (GERD) and Zollinger-Ellison syndrome by reducing gastric acid production.Microspheres, designed for extended drug delivery and enhanced bioavailability, were formulated and evaluated in this study.Aim: To develop ranitidine hydrochloride microspheres capable of prolonging drug delivery and improving bioavailability.Methods: The inotropic gelation method was utilized to prepare alginate microspheres incorporating polymers such as ethyl cellulose, sodium carboxymethyl cellulose, HPMC, and carbopol.The resulting drug-loaded microspheres exhibited spherical rigidity after crosslinking with a 10% w/v calcium chloride solution.Evaluation parameters including Fourier transform infra-red (FTIR) analysis, precompression characteristics, percentage yield, swelling index, and drug content were determined.Results: The FTIR results obtained, showed there was no incompatibility among the excipients and the active pharmaceutical ingredient.The Scanning electron microscopy (SEM) obtained, indicated the presence of spherical particles present in the formulation.The precompression evaluation showed that the angle of repose ranged from 4.85 0.02 to 7.22 0.06o for batched F4 and F1 respectively, while the Carr's index ranged from 73.5 2.47 % to 87.00 3.53 % for batches F-7 and F-1 respectively.The percentage yield ranged from 73.5 2.47 % to 87.00 3.53 % for batches F-7 and F-1 respectively.In vitro drug release studies revealed sustained drug release over 4 hours, with a maximum release of 69.50 1.77 % observed for batch F-1.Conclusion: Overall, the optimised formulated ranitidine hydrochloride microsphere (F-1) demonstrated prolonged and controlled release characteristics, indicating its potential