Formulation and in Vitro Evaluation of Liquisolid Compact of Celecoxib

Introduction:The pharmaceutical liquisolid technique has emerged as a promising approach for addressing the challenges associated with poorly water-soluble drugs.The solubility and bioavailability of drugs play a pivotal role in determining their therapeutic efficacy.Aim: To formulate and evaluate celecoxib tablets using the liquisolid technique, in order to enhance its dissolution rate and bioavailability.Method: Celecoxib tablets were prepared using the liquisolid technique by incorporating a nonvolatile liquid medication carrier and a suitable coating material.Various formulations were developed by altering the ratios of drug, carrier, and coating materials.The prepared tablets were characterized for their physical properties, drug content uniformity, in vitro dissolution behavior, compatibility using Fourier-transform infrared (FTIR) spectroscopy, morphology using Scanning electron microscopy (SEM) and enthalpy changes using Differential scanning calorimetry (DSC).Results: The solubility profile showed that the maximum rate of dissolution was recorded in PEG-400 (11.03 0.01) when compared to other non-volatile solvents.The angle of slide, indicated that the excipients used were within the acceptable limit of 33o.The FTIR spectroscopy showed compatibility of the drug and excipients.The results of the SEM showed that sphericallyshaped vesicles were formed.DSC showed the crystallinity nature of the excipients and the amorphous nature of the optimized formulation.Evaluation of the pre-compression parameters indicated that the drug content was highest in batch F-11 hence its optimization (96.1 0.90 %).The post compression evaluation indicated that the official tests were within the acceptable range for disintegration time (2.25 0.35 mins).