The genomic landscape of transformed splenic diffuse red pulp small B‐cell lymphoma
The genetic landscape underlying the transformation of splenic diffuse red pulp small B-cell lymphoma (SDRPL) is not well understood. The present study aimed to unravel the genomic alterations involved in the progression and transformation of SDRPL. We performed genetic studies on both SDRPL and subsequent or synchronous diffuse large B cell lymphoma (DLBCL) samples in three SDRPL patients who eventually developed DLBCL. Our findings revealed that SDRPL cases progressing to DLBCL acquired genomic alterations in genes related to the cell cycle (<i>CDKN2A/B, TP53, MYC</i> and <i>CCND3</i>) and B cell development (<i>BCL6</i>).
Authors
- Mònica López‐Guerra (ORCID: https://orcid.org/0000-0002-5545-0178)
- Olga Balagué (ORCID: https://orcid.org/0000-0002-5099-3675)
- Sílvia Ruiz-Gaspà
- Gerard Frigola (ORCID: https://orcid.org/0000-0001-6794-6456)
- Elı́as Campo (ORCID: https://orcid.org/0000-0001-9850-9793)
- Cristina López (ORCID: https://orcid.org/0000-0001-6644-1659)
- Juan Gonzalo Correa (ORCID: https://orcid.org/0000-0001-6470-8102)
- Marta Grau (ORCID: https://orcid.org/0000-0003-3779-0387)
- Anna Montaner
- Eva Giné (ORCID: https://orcid.org/0000-0002-0532-1204)
- Ferran Nadeu (ORCID: https://orcid.org/0000-0003-2910-9440)
- Pablo Mozas (ORCID: https://orcid.org/0000-0001-9528-4971)
- Estella Matutes (ORCID: https://orcid.org/0000-0001-6745-7046)
- Sı́lvia Beà (ORCID: https://orcid.org/0000-0001-7192-2385)
- Dolors Colomer (ORCID: https://orcid.org/0000-0001-7486-8484)
- José Ramón Álamo Moreno (ORCID: https://orcid.org/0000-0001-8579-082X)
- Melina Pol (ORCID: https://orcid.org/0000-0002-4670-4252)
- Daniel Martı́nez
- Alba Navarro (ORCID: https://orcid.org/0000-0002-4041-0974)
- Melika Bashiri
- Ian Márquez‐López
- Armando López‐Guillermo
Institutions
- Hospital Clínic de Barcelona (ES)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- eJHaem
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/jha2.1018
- Citations
- 1
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Instituto de Salud Carlos III