5-Hydroxymethylcytosine in circulating cell-free DNA as a potential diagnostic biomarker for SLE
Our findings demonstrate the increased 5hmC distribution in plasma cfDNA in different disease activity in patients with SLE compared with HCs and relating DhMRs involved in SLE-associated pathways. Furthermore, we identified a panel of SLE relevant biomarkers, and these viewpoints could provide insight into the pathogenesis of SLE.
Authors
- Xinya Tong
- Gangqiang Guo (ORCID: https://orcid.org/0000-0001-8031-7937)
- Xin‐Qi Zhu (ORCID: https://orcid.org/0009-0006-7488-8251)
- Huidi Zhang (ORCID: https://orcid.org/0000-0001-9671-8401)
- Lele Ye (ORCID: https://orcid.org/0000-0002-6741-8626)
- Xinhang Xia (ORCID: https://orcid.org/0000-0001-6407-3469)
- Wenwen Chen (ORCID: https://orcid.org/0000-0003-0277-0941)
- Zexia Xu
- Yuan Xu (ORCID: https://orcid.org/0000-0002-2837-2952)
- Yutong Lin (ORCID: https://orcid.org/0000-0001-8038-4064)
- Yanling Xiong
- Yunhui Luo
- Xiangyang Xue
- Nan Wang (ORCID: https://orcid.org/0009-0001-3237-5339)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Lupus Science & Medicine
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1136/lupus-2024-001286
- Citations
- 5
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China
- Wenzhou Municipal Science and Technology Bureau
- Natural Science Foundation of Zhejiang Province