The temporal dynamics of the gut mycobiome and its association with cardiometabolic health in a nationwide cohort of 12,641 Chinese adults
The dynamics of the gut mycobiome and its association with cardiometabolic health remain largely unexplored. Here, we employ internal transcribed spacer (ITS) sequencing to capture the gut mycobiome composition and dynamics within a nationwide human cohort of 12,641 Chinese participants, including 1,946 participants with repeated measurements across three years. We find that the gut mycobiome is associated with cardiometabolic diseases and related biomarkers in both cross-sectional and dynamic analyses. Fungal alpha diversity indices and 19 mycobiome genera are the major contributors to the mycobiome-cardiometabolic disease link. Particularly, Saccharomyces emerges as an effect modifier of traditional risk factors in promoting type 2 diabetes risk. Further integration of multi-omics data reveals key metabolites such as γ-linolenic acid and L-valine linking the gut mycobiome to type 2 diabetes. This study advances our understanding of the potential roles of the gut mycobiome in cardiometabolic health.
Authors
- Chang Su (ORCID: https://orcid.org/0000-0003-1285-3724)
- Wenwen Du (ORCID: https://orcid.org/0000-0002-4476-2985)
- Yuanqing Fu (ORCID: https://orcid.org/0000-0002-3955-9376)
- Jiguo Zhang (ORCID: https://orcid.org/0000-0003-3266-8999)
- Bing Zhang (ORCID: https://orcid.org/0000-0001-9774-517X)
- Menglei Shuai (ORCID: https://orcid.org/0000-0001-9983-1477)
- Ju‐Sheng Zheng (ORCID: https://orcid.org/0000-0001-6560-4890)
- Ke Zhang (ORCID: https://orcid.org/0000-0002-4562-5405)
- Huijun Wang (ORCID: https://orcid.org/0000-0002-8064-4564)
- Chang Gao (ORCID: https://orcid.org/0000-0002-1207-7457)
- Xiaofang Jia (ORCID: https://orcid.org/0000-0002-7127-0011)
- Wanglong Gou (ORCID: https://orcid.org/0000-0002-4256-9452)
- Zelei Miao (ORCID: https://orcid.org/0000-0001-9478-1933)
- Xinyu Wang (ORCID: https://orcid.org/0009-0004-9019-4810)
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- Westlake University (CN)
Publication Details
- Journal
- Cell Reports Medicine
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1016/j.xcrm.2024.101775
- Citations
- 6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Westlake University
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- Carolina Population Center, University of North Carolina at Chapel Hill