Parathyroid carcinoma and atypical parathyroid tumor: analysis of an Italian database
Atypical parathyroid tumors and PCs showed no significant differences in many clinical features and presented similar values of elevated parathyroid hormone and total serum calcium. Renal complications, namely nephrolithiasis and nephrocalcinosis, appeared to be more common in PC, with a significantly higher rate of renal colic, regardless of total serum calcium levels and 24-h calciuria. Parathyroid carcinomas showed significantly higher postoperative disease persistence and recurrence rates, presumably due to an uncomplete resection of the primary tumor in 23.5% of cases and/or presence of unremoved active metastasis, but they had similar disease-free mean time after surgery than aPT. To deepen the study of malignant parathyroid tumors, the institution of a novel Italian retro-prospective multicenter registry of aPTs and PCs is currently ongoing, and a dedicated PC European registry has been recently activated.
Authors
- Emanuela Arvat (ORCID: https://orcid.org/0000-0001-5689-4400)
- Giuliano Perigli (ORCID: https://orcid.org/0000-0002-2271-5766)
- Paola Loli (ORCID: https://orcid.org/0000-0002-5545-550X)
- Salvatore Benvenga (ORCID: https://orcid.org/0000-0002-6391-5342)
- Maurizio Iacobone (ORCID: https://orcid.org/0000-0002-6057-4642)
- Andrea Repaci (ORCID: https://orcid.org/0000-0002-8061-8147)
- Francesca Giusti (ORCID: https://orcid.org/0000-0002-8576-9606)
- Laura Castellino
- Lara Vera
- Marco Piovesan (ORCID: https://orcid.org/0000-0002-5721-3053)
- Giovanna Mantovani (ORCID: https://orcid.org/0000-0002-9065-3886)
- Maria Vittoria Davì (ORCID: https://orcid.org/0000-0002-6076-4411)
- Maria Chiara Zatelli (ORCID: https://orcid.org/0000-0001-8408-7796)
- Gemma Marcucci (ORCID: https://orcid.org/0000-0003-0579-0542)
- Diego Ferone (ORCID: https://orcid.org/0000-0002-1410-6143)
- Sabrina Corbetta (ORCID: https://orcid.org/0000-0001-8140-3175)
- Maria Luisa Brandi (ORCID: https://orcid.org/0000-0002-8741-0592)
- Valentina Camozzi (ORCID: https://orcid.org/0000-0002-1634-951X)
- Uberto Pagotto (ORCID: https://orcid.org/0000-0003-4182-3110)
- Luca Persani (ORCID: https://orcid.org/0000-0003-2068-9581)
- Rosaria Maddalena Ruggeri (ORCID: https://orcid.org/0000-0001-8899-684X)
- Marta Bondanelli (ORCID: https://orcid.org/0000-0001-8071-6559)
- Guido Zavatta (ORCID: https://orcid.org/0000-0003-3657-2070)
- Francesca Marini (ORCID: https://orcid.org/0000-0002-3678-4922)
- Cristina Eller-Vainicher
- Fausto Famà
Institutions
- University of Messina (IT)
- University of Verona (IT)
- University of Padua (IT)
- Vita-Salute San Raffaele University (IT)
- Morpho (United States) (US)
- University of Milan (IT)
- University of Ferrara (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Azienda USL di Bologna (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Ospedale Policlinico San Martino (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Florence (IT)
- University of Turin (IT)
- University of Genoa (IT)
- University of Bologna (IT)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1093/ejendo/lvae121
- Citations
- 9
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.05
Funders
- Ministero della Salute