Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells
This study demonstrated a potent GUCY2C-targeted CAR-T cell for gastrointestinal tumor therapy and highlights the importance of adequate tonic signaling for effective CAR-T cell therapy against solid tumors.
Authors
- Fei Dai (ORCID: https://orcid.org/0009-0003-9309-5992)
- Changsong Qi (ORCID: https://orcid.org/0000-0001-9157-3768)
- Mingyang Ma (ORCID: https://orcid.org/0000-0002-2944-628X)
- D Y Liu (ORCID: https://orcid.org/0000-0003-4656-9131)
- Chang Liu (ORCID: https://orcid.org/0000-0001-8489-2605)
- Lin Shen (ORCID: https://orcid.org/0000-0003-1134-2922)
- Xin‐an Lu (ORCID: https://orcid.org/0000-0003-4721-1684)
- Jian Li (ORCID: https://orcid.org/0000-0001-9392-9449)
- Xicheng Wang (ORCID: https://orcid.org/0000-0001-6677-850X)
- Min Tao (ORCID: https://orcid.org/0000-0001-8129-145X)
- Xiaofei Wei (ORCID: https://orcid.org/0009-0006-8391-4204)
- Ting He
- Yanping Ding
- Cheng Zhang (ORCID: https://orcid.org/0000-0001-5386-4708)
Institutions
- Peking University (CN)
- China National Pharmaceutical Group Corporation (China) (CN)
- Peking University Cancer Hospital (CN)
- Ministry of Education (ET)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1136/jitc-2024-009960
- Citations
- 9
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.54
Funders
- Peking University
- Fundamental Research Funds for the Central Universities