Pharmacological modulation of transglutaminase 2 in the unilateral ureteral obstruction mouse model
Renal TG2 mRNA and protein expression levels seem dissociated, with transamidase activity being increased. LDN27219 influences kidney pro-fibrotic markers at the mRNA level and attenuates transamidase activity but without affecting collagen content or BP. Our findings suggest that TG2 in its closed conformation has anti-fibrotic effects at the molecular level.
Authors
- Isabela Bastos Binotti Abreu de Araujo
- Ulf Simonsen (ORCID: https://orcid.org/0000-0002-2169-7666)
- Augusto C. Montezano (ORCID: https://orcid.org/0000-0002-8658-7994)
- Rhian M. Touyz (ORCID: https://orcid.org/0000-0003-0670-0887)
- Judit Prat‐Duran (ORCID: https://orcid.org/0000-0001-8241-1636)
- E. Pinilla (ORCID: https://orcid.org/0000-0002-7852-992X)
- Nina Juste
- Niels Henrik Buus (ORCID: https://orcid.org/0000-0001-7972-8181)
- Rikke Nørregaard (ORCID: https://orcid.org/0000-0002-0580-373X)
- Francisco J. Rios (ORCID: https://orcid.org/0000-0002-8194-0787)
Institutions
- Aarhus University (DK)
- McGill University Health Centre (CA)
- Aarhus University Hospital (DK)
- Institute for Biomedicine (IT)
Publication Details
- Journal
- European Journal of Pharmacology
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1016/j.ejphar.2024.177037
- Citations
- 3
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- Aarhus Universitet
- Hørslev-Fonden
- Aarhus Universitets Forskningsfond
- Novo Nordisk Fonden