Severe mpox in an immunocompromised patient complicated by deep tissue infection: A case report
Our data provide evidence that Tecovirimat treatment selects for compartimentalized viral mutations (A288P). While the patient clinically benefited from repeated tecovirimat course, emergence of viral muations and deep tissue infection emphasizes the challenge and importance of infectious disease monitoring in mpox patient management.
Authors
- Michaela Schweizer (ORCID: https://orcid.org/0000-0001-5062-328X)
- Ronald von Possel (ORCID: https://orcid.org/0000-0001-9422-9401)
- Susanne Krasemann (ORCID: https://orcid.org/0000-0001-8795-818X)
- Susanne Pfefferle (ORCID: https://orcid.org/0000-0001-7489-6557)
- Petra Emmerich (ORCID: https://orcid.org/0000-0001-5093-4539)
- Martin Aepfelbacher (ORCID: https://orcid.org/0000-0003-2473-2970)
- Lisa Sophie Pflüger (ORCID: https://orcid.org/0009-0009-1649-5312)
- Dominik Nörz (ORCID: https://orcid.org/0000-0003-4001-7192)
- J.M. Berger (ORCID: https://orcid.org/0000-0002-1695-8577)
- Stefan Schmiedel (ORCID: https://orcid.org/0000-0002-6910-8461)
- Katja Giersch (ORCID: https://orcid.org/0000-0003-3989-0170)
- Markus Glatzel (ORCID: https://orcid.org/0000-0002-7720-8817)
- Thomas Theo Brehm (ORCID: https://orcid.org/0000-0003-1737-161X)
- Christian Bernreuther (ORCID: https://orcid.org/0000-0003-3939-322X)
- Nicole Fischer (ORCID: https://orcid.org/0000-0002-5092-8179)
- A. Hartmann (ORCID: https://orcid.org/0000-0001-8699-0794)
- Julian Schulze Zur Wisch
- Marc Lütgehetmann (ORCID: https://orcid.org/0000-0002-9468-7944)
Institutions
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- German Center for Infection Research (DE)
- Bernhard Nocht Institute for Tropical Medicine (DE)
Publication Details
- Journal
- Heliyon
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38873
- Citations
- 5
- Primary Topic
- Poxvirus research and outbreaks
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases