Endothelial pyroptosis-driven microglial activation in choroid plexus mediates neuronal apoptosis in hemorrhagic stroke rats
Our study provides evidence that endothelial pyroptosis, characterized by the release of IL-1β and IL-6, triggers microglial polarization through NF-κB pathway activation, ultimately leading to microglia-mediated neuronal apoptosis in the choroid plexus post-ICH. These findings suggest that targeted therapeutic strategies aimed at mitigating endothelial cell pyroptosis and neutralizing inflammatory cytokines may offer neuroprotection for both microglia and neurons, presenting a promising avenue for ICH treatment.
Authors
- Xinjie Bao (ORCID: https://orcid.org/0000-0003-2117-7692)
- Ruxu Geng
- Jianbo Chang (ORCID: https://orcid.org/0000-0002-0192-3881)
- Liguo Ye (ORCID: https://orcid.org/0000-0003-4816-2765)
- Mingjiang Sun
- Tingyu Liang (ORCID: https://orcid.org/0009-0004-6079-6968)
- Junji Wei
- Jiashun Xiao (ORCID: https://orcid.org/0000-0002-0130-2102)
- Lingui Gu
- Renzhi Wang (ORCID: https://orcid.org/0000-0003-2080-5474)
- Yi‐Hao Chen (ORCID: https://orcid.org/0000-0002-9977-7180)
- Hualin Chen (ORCID: https://orcid.org/0000-0002-8908-5092)
- Wenbin Ma (ORCID: https://orcid.org/0000-0001-8774-7593)
- Gui Wan
- Qinglei Shi
- Zhuo Wang (ORCID: https://orcid.org/0009-0002-2315-8604)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Shenzhen Research Institute of Big Data (CN)
- Beijing Institute of Neurosurgery (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1016/j.nbd.2024.106695
- Citations
- 12
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.97