The molecular mechanisms of Caulophyllum robustum Maxim extract inhibition by regulating FAK/PI3K signaling pathway in gastric cancer HGC-27 cells
The anti-tumor components of CRME, Cauloside A and Cauloside C, inhibited tumor progression in HGC-27 cells. This inhibition is achieved by decreasing the phosphorylation levels of FAK, thereby modulating PI3K/AKT signaling pathway.
Authors
- Xiangshan Ren (ORCID: https://orcid.org/0000-0003-0914-1814)
- Jingchun Jin (ORCID: https://orcid.org/0000-0002-3985-2513)
- Yingying Zhang (ORCID: https://orcid.org/0000-0002-8448-3059)
- Guangyuan Yao (ORCID: https://orcid.org/0000-0003-0897-2237)
- Zhenhua Lin (ORCID: https://orcid.org/0000-0003-0279-3166)
- Shengjun Zhang (ORCID: https://orcid.org/0000-0002-7108-0760)
- Yingshi Piao (ORCID: https://orcid.org/0000-0002-7466-1595)
- Ren‐Bo An (ORCID: https://orcid.org/0000-0002-2564-0747)
- Meixin Wen
- Minghua Cui (ORCID: https://orcid.org/0009-0002-8148-1215)
Institutions
- Yanbian University (CN)
- State Ethnic Affairs Commission (CN)
- Chifeng Municipal Hospital (CN)
- Yanbian University Hospital (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1016/j.jep.2024.118867
- Citations
- 2
- Primary Topic
- Phytochemistry and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.35
Funders
- National Natural Science Foundation of China
- Jilin Provincial Health and Family Planning Commission
- Jilin Scientific and Technological Development Program