Generation of a gene-corrected isogenic human iPSC line (CSUASOi006-A-1) from a retinitis pigmentosa patient with heterozygous c.5792C > T mutation in the PRPF8 gene
Retinitis pigmentosa (RP) is a common inherited retinal disease characterized by progressive degeneration of the retina, leading to night blindness, progressive vision loss, and constriction of the visual field. Previously, we established a human induced pluripotent stem cell line (CSUASOi006-A) from a RP patient carrying heterozygous PRPF8 (c.C5792T) mutation. Here, we corrected the mutation sites in PRPF8 (c.C5792T) using an adenine base editor and then generated an isogenic control (CSUASOi006-A-1), which is a valuable cell resource for research of RP.
Authors
- Xihao Sun (ORCID: https://orcid.org/0000-0002-3470-2006)
- Jiansu Chen (ORCID: https://orcid.org/0000-0001-7332-8427)
- Yuqin Liang (ORCID: https://orcid.org/0000-0002-2448-4746)
- Zekai Cui (ORCID: https://orcid.org/0000-0003-3670-6219)
- Shibo Tang (ORCID: https://orcid.org/0000-0003-2737-6780)
- Yalan Zhou
- Xujie Liu (ORCID: https://orcid.org/0000-0001-8713-4287)
- Shengru Mao
- Chunwen Duan
- Jianing Gu (ORCID: https://orcid.org/0000-0003-2241-5533)
- Chengcheng Ding
Institutions
- Central South University (CN)
- Jinan University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Second Xiangya Hospital of Central South University (CN)
- He Eye Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Affiliated Hospital of Jining Medical University (CN)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1016/j.scr.2024.103572
- Citations
- 2
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47