Clostridioides difficile toxin B suppresses human neutrophil migration
We investigated the effects of Clostridioides difficile toxin B (TcdB), a major virulence factor in C. difficile infection (CDI), on human neutrophils. TcdB inhibits neutrophil migration via loss of polarity of F-actin polymerization in response to interleukin-8. TcdB facilitates CDI by allowing C. difficile to avert the host immune system.
Authors
- Nami Hatayama (ORCID: https://orcid.org/0009-0008-4927-0219)
- Yusuke Yoshino (ORCID: https://orcid.org/0000-0002-3633-4243)
- Yoshinori Sato (ORCID: https://orcid.org/0000-0001-8250-6598)
- Yoshitaka Kimura (ORCID: https://orcid.org/0000-0001-5430-9909)
Institutions
- Teikyo University (JP)
Publication Details
- Journal
- Anaerobe
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1016/j.anaerobe.2024.102916
- Citations
- 2
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.78
Funders
- Japan Society for the Promotion of Science