Notch-Driven Cholangiocarcinogenesis Involves the Hippo Pathway Effector TAZ via METTL3-m6A-YTHDF1
This study describes a novel Notch-METTL3-TAZ signaling cascade, which is important in CCA development and progression. Our experimental results provide new insight into how the Notch pathway cooperates with TAZ signaling in CCA, and the findings may have important therapeutic implications.
Authors
- Nianli Liu (ORCID: https://orcid.org/0000-0002-0602-6709)
- Weina Chen (ORCID: https://orcid.org/0000-0001-5638-4371)
- Jinqiang Zhang (ORCID: https://orcid.org/0000-0001-9594-276X)
- Tong Wu (ORCID: https://orcid.org/0000-0003-3792-0153)
- Wenbo Ma (ORCID: https://orcid.org/0000-0003-3273-5960)
Institutions
- Tulane University (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1016/j.jcmgh.2024.101417
- Citations
- 4
- Primary Topic
- Law, logistics, and international trade
- Type
- article
- Field-Weighted Citation Impact
- 3.78
Funders
- National Institutes of Health