Chronic ethanol exposure in mice evokes pre‐ and postsynaptic deficits in GABAergic transmission in ventral tegmental area GABA neurons
Chronic ethanol weakens the GABAergic regulation of VTA GABA neurons in mice via pre- and postsynaptic mechanisms, likely contributing to their elevated activity during withdrawal and expression of anxiety-related behaviour. As anxiety can promote relapse during abstinence, interventions targeting VTA GABA neuron excitability could represent new therapeutic strategies for treatment of alcohol use disorder.
Authors
- Carolina Aguado (ORCID: https://orcid.org/0000-0003-0265-8124)
- Eric H. Mitten (ORCID: https://orcid.org/0000-0001-7017-9083)
- Rafael Luján (ORCID: https://orcid.org/0000-0003-2001-9545)
- Kevin Wickman (ORCID: https://orcid.org/0000-0002-5179-9540)
- Anna Souders
- Ezequiel Marrón Fernández de Velasco (ORCID: https://orcid.org/0000-0003-0257-4457)
Institutions
- University of Minnesota (US)
- Institut de Biomedicina de la Universitat de Barcelona
- University of Castilla-La Mancha (ES)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1111/bph.17335
- Citations
- 6
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- University of Minnesota
- Ministerio de Ciencia, Innovación y Universidades
- Universidad de Castilla-La Mancha
- Junta de Comunidades de Castilla-La Mancha
- National Institutes of Health
- European Regional Development Fund
- Agencia Estatal de Investigación
- National Institute on Drug Abuse
- National Institute of Neurological Disorders and Stroke
- National Center for Advancing Translational Sciences