Academic outcomes before and after clinical onset of acquired demyelinating syndromes in children: a matched cohort data linkage study

It is unknown if cognition is impaired before clinical onset of paediatric acquired demyelinating syndromes. We conducted a matched cohort study using prospectively collected educational data in multiple sclerosis (MS) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) patients (n = 60) and controls (pooled n = 449,553). Academic performance at ages 10-11 was impaired in MOGAD (-1.27 adjusted z-score [95% CI: -1.81 to -0.73], P < 0.001) and preclinical MS (-0.40 [-0.80 to -0.0003], P = 0.0498). Moderate/high-efficacy MS treatment was associated with better final academic performance (0.92 [0.28-1.57], P = 0.005). After clinical onset MS patients missed 8.7% of school (controls 2.9%, P < 0.001) and MOGAD patients 11.9% (controls 2.0%, P < 0.001).

Authors

Institutions

Publication Details

Journal
Annals of Clinical and Translational Neurology
Published
2024-10-02
DOI
https://doi.org/10.1002/acn3.52198
Citations
6
Primary Topic
Multiple Sclerosis Research Studies
Type
article
Field-Weighted Citation Impact
2.55

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Academic outcomes before and after clinical onset of acquired demyelinating syndromes in children: a matched cohort data linkage study

Sarah R. Rudebeck, Ming Lim, Omar Abdel‐Mannan, Yael Hacohen et al.
6 citations
Annals of Clinical and Translational Neurology
Multiple Sclerosis Research Studies
2.55
article

Academic outcomes before and after clinical onset of acquired demyelinating syndromes in children: a matched cohort data linkage study

Sarah R. Rudebeck, Ming Lim, Omar Abdel‐Mannan, Yael Hacohen, Sarah Crichton, Michael Absoud, Cheryl Hemingway, Thomas Rossor, Michael Eyre, Gavin Giovannoni
article en
6 citations

Abstract

It is unknown if cognition is impaired before clinical onset of paediatric acquired demyelinating syndromes. We conducted a matched cohort study using prospectively collected educational data in multiple sclerosis (MS) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) patients (n = 60) and controls (pooled n = 449,553). Academic performance at ages 10-11 was impaired in MOGAD (-1.27 adjusted z-score [95% CI: -1.81 to -0.73], P < 0.001) and preclinical MS (-0.40 [-0.80 to -0.0003], P = 0.0498). Moderate/high-efficacy MS treatment was associated with better final academic performance (0.92 [0.28-1.57], P = 0.005). After clinical onset MS patients missed 8.7% of school (controls 2.9%, P < 0.001) and MOGAD patients 11.9% (controls 2.0%, P < 0.001).

Annals of Clinical and Translational NeurologyVol. 11(11)
Queen Mary University of London (GB), King's College London (GB), Guy's and St Thomas' NHS Foundation Trust (GB), Great Ormond Street Hospital (GB), Evelina London Children's Healthcare (GB), National Hospital for Neurology and Neurosurgery (GB), King's College Hospital (GB), University College London (GB)
Action Medical Research, Medical Research Council
Quality Education
Openalex Percentile: Top 10%
Multiple Sclerosis Research Studies
2.55
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.