Cholinergic dysfunction in isolated rapid eye movement sleep behaviour disorder links to impending phenoconversion
These findings suggest that cortical cholinergic dysfunction, particularly within the parietal cortex, could be a biomarker candidate for predicting short-term phenoconversion in iRBD patients. This study aligns with previous reports suggesting dopaminergic dysfunction is associated with forthcoming phenoconversion.
Authors
- Alícia Garrido (ORCID: https://orcid.org/0000-0003-0652-6348)
- Per Borghammer (ORCID: https://orcid.org/0000-0001-6391-8052)
- Arne Møller (ORCID: https://orcid.org/0000-0002-0061-2774)
- Mónica Serradell (ORCID: https://orcid.org/0000-0002-2954-3020)
- Nicola Pavese (ORCID: https://orcid.org/0000-0002-6801-6194)
- Erik Johnsen (ORCID: https://orcid.org/0000-0002-7465-319X)
- Joan Santamaría (ORCID: https://orcid.org/0000-0003-0879-4135)
- David J. Brooks (ORCID: https://orcid.org/0000-0003-2602-2518)
- Miriam Højholt Terkelsen (ORCID: https://orcid.org/0000-0003-0971-3747)
- Andreas Myhre Baun (ORCID: https://orcid.org/0009-0007-8099-1367)
- Mette Møller (ORCID: https://orcid.org/0000-0002-0012-8691)
- Morten Gersel Stokholm (ORCID: https://orcid.org/0000-0003-1098-7710)
- Marit Otto (ORCID: https://orcid.org/0000-0002-1508-9269)
- Dolores Vilas (ORCID: https://orcid.org/0000-0003-3084-053X)
- Karen Østergaard (ORCID: https://orcid.org/0000-0003-4829-9761)
- Carles Gaig
- Kristina B. Svendsen
- Erik Hvid Danielsen
- Álex Iranzo
- E. Tolosa
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Hospital Clínic de Barcelona (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
- Newcastle University (GB)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1111/ene.16503
- Citations
- 5
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- Parkinsonforeningen
- Danmarks Frie Forskningsfond
- Augustinus Fonden
- Instituto de Salud Carlos III