Understand the Fatty Acid Metabolic Reprogramming of Immune Cells in Colorectal Cancer

Colorectal cancer (CRC) is a prevalent and challenging type of cancer worldwide. Recent research has focused intensively on understanding the molecular and pathological mechanisms of CRC because of the poor prognosis associated with its treatment. The tumor microenvironment (TME) is crucial in tumor progression and has been the subject of extensive investigation. Metabolic reprogramming has become a central focus in cancer research, with numerous studies emphasizing its importance in CRC.Specifically, the reprogramming of fatty acids has been found to alter the energy and nutrient composition within the tumor microenvironment, affecting the complex interaction between immune cells, especially macrophages and T cells, and associated immune factors.This disruption can influence the tumor's ability to evade immune surveillance.Our in-depth analysis highlights the role of lipid metabolism processes in shaping the immune microenvironment of colorectal cancer tumors, revealing the regulatory impact of fatty acid metabolism on CRC development.The potential impact of this research on improving CRC treatment is significant, underscoring the importance of contribution to this field.