Soybean Isoflavones Alleviate Osteoarthritis Through Modulation of the TSC1/mTORC1 Signaling Pathway to Reduce Intrachondral Angiogenesis
SI targets the TSC1/mTORC1 signaling pathway to suppress osteoblast activation and VEGF release, inhibiting type H vessel formation and slowing abnormal subchondral bone remodeling. These findings provide a novel therapeutic approach for OA by focusing on subchondral bone remodeling mechanisms.
Authors
- Jiong Hu (ORCID: https://orcid.org/0000-0002-5613-1195)
- Zhaoyang Wang (ORCID: https://orcid.org/0000-0001-8309-6746)
- Weifeng Hu
- Hangchu Shi
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Immunological Investigations
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1080/08820139.2024.2410737
- Citations
- 5
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.35