Comparison of maternal circulating collectrin levels between normal pregnancies and pregnancies complicated by oligohydramnios and fetal growth restriction

Objective: Collectrin is a transmembrane regulatory glycoprotein involved in the renin-angiotensin system and plays an important role in kidney development. It is well known that placental perfusion play essential role in maintaining amniotic fluid production and fetal development. The current study sought to assess the relationship between serum collectrin levels and fetal growth restriction (FGR) and oligohydramnios. Methods: This observational study was done in a tertiary level maternity hospital. The study groups were comprised of pregnancies complicated with term oligohydramniosis and isolated FGR. The control group was selected from among low risk healthy pregnancies. Demographic features, obstetric characteristics, gestational age, amniotic fluid index, fetal biometric measurements, doppler indices, blood pressure, pulse, hematologic, and biochemical parameters, and serum collectrin levels were recorded for each patient. Results: No significant differences were observed among the groups with regard to maternal age, body mass index, gesational week, and peripheral blood pressures (p>0.05). The birth weights were statistically significantly lower in the FGR group than the other 2 groups (p