High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis
Mechanistically guided drug repurposing has been made possible by systematically integrating pharmacologic and CRISPR-Cas9 screen data. Our study discovers the biomarker and cell death mechanisms underpinning sensitivity toward AZD5582, an antagonist of the inhibitor of apoptosis family protein. Our findings have important implications for improving future trial design for patients with OSCC using this emerging drug class.
Authors
- Syd Barthorpe
- Sok Ching Cheong (ORCID: https://orcid.org/0000-0002-6765-9542)
- Pei San Yee (ORCID: https://orcid.org/0000-0002-6548-2149)
- Annie Wai Yeeng Chai (ORCID: https://orcid.org/0000-0002-8015-6050)
- Yee Hua Tan
- Shiyin Ooi (ORCID: https://orcid.org/0000-0002-6165-111X)
- Shi Mun Yee (ORCID: https://orcid.org/0009-0007-9858-1817)
- Howard Lightfoot (ORCID: https://orcid.org/0000-0003-2082-9986)
- Mathew J. Garnett (ORCID: https://orcid.org/0000-0002-2618-4237)
Institutions
- Wellcome Sanger Institute (GB)
- University of Malaya (MY)
- Cancer Research Malaysia (MY)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0136
- Citations
- 1
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.23