Preferred Lung Accumulation of Polystyrene Nanoplastics with Negative Charges
With the increasing presence of nanoplastics (NPs) in the human bloodstream, it is urgent to investigate their tissue accumulation and potential health risks. This study examines the effects of the size and surface charges of polystyrene (PS) NPs on lung accumulation. Using magnetic separation, we identified the protein corona composition on iron-core PS NPs, revealing the enrichment of vitronectin and fibrinogen. The corona promotes integrin α<sub>IIb</sub>β<sub>3</sub> receptor-mediated uptake by lung endothelial cells, explaining that both the corona composition and protein structure determine preferred localization of negatively charged PS NPs in the lung. This study uncovers the role of protein corona in NP uptake and the way NPs enter the lung, emphasizing the need to consider interactions between nanoplastics with varying surface characteristics and biological molecules in the nanotoxicological field.
Authors
- Didar Baimanov (ORCID: https://orcid.org/0000-0002-5805-3303)
- Qingxi Yuan (ORCID: https://orcid.org/0000-0002-2997-7654)
- Zhiyong Zhang (ORCID: https://orcid.org/0000-0001-9753-0873)
- Liming Wang (ORCID: https://orcid.org/0000-0003-1382-9195)
- Zehao Zhang (ORCID: https://orcid.org/0009-0003-9196-8999)
- Zhuda Song
- Yuxi Gao
- Wanxia Huang (ORCID: https://orcid.org/0009-0001-4101-2820)
- Longxing Sun
Institutions
- Chinese Academy of Sciences (CN)
- Institute of High Energy Physics (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Nano Letters
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1021/acs.nanolett.4c03245
- Citations
- 7
- Primary Topic
- Microplastics and Plastic Pollution
- Type
- article
- Field-Weighted Citation Impact
- 0.93
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Beijing Municipal Natural Science Foundation
- National Key Research and Development Program of China