Schistosoma japonicum infection-mediated downregulation of lncRNA Malat1 contributes to schistosomiasis hepatic fibrosis by the Malat1/miR-96/Smad7 pathway
We demonstrate that lncRNA is involved in regulation of schistosomiasis HF. Elevated lncRNA Malat1 expression in infected HSCs reduces fibrosis via the Malat1/miR-96/Smad7 pathway, thus providing a novel therapeutic target for schistosomiasis HF. Furthermore, Malat1 expression is sensitive to PZQ treatment, thus offering a potential biomarker for assessing the response to chemotherapy.
Authors
- Weiqing Pan (ORCID: https://orcid.org/0000-0003-2224-3241)
- Yini Tian
- Dongmei Zhang (ORCID: https://orcid.org/0000-0001-6180-0253)
- Xiaobin Fan
- Pengyue Jiang
- Shengyu Ye
Institutions
- Tongji University (CN)
- Naval Medical Research Command (US)
- Second Military Medical University (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1186/s13071-024-06499-9
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- National Natural Science Foundation of China