A virus-derived enzyme can destroy the membrane structures that protect bacteria

Bacteria in the gut have been shown to cause the severe side effects associated with treating blood diseases with genetically dissimilar, and thus immunologically incompatible, blood stem cells (allogeneic haematopoietic cell transplantation). An enzyme derived from viruses that infect these bacteria demonstrates potential for eradication therapy. A previously unknown enzyme can kill the bacteria that cause graft-versus-host disease in the treatment of blood disorders.

Publication Details

Journal
Nature
Published
2024-10-03
DOI
https://doi.org/10.1038/d41586-024-03188-6
Primary Topic
Bacteriophages and microbial interactions
Type
article
Field-Weighted Citation Impact
0.00
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article

A virus-derived enzyme can destroy the membrane structures that protect bacteria

Nature
Bacteriophages and microbial interactions
article

A virus-derived enzyme can destroy the membrane structures that protect bacteria

article en

Abstract

Bacteria in the gut have been shown to cause the severe side effects associated with treating blood diseases with genetically dissimilar, and thus immunologically incompatible, blood stem cells (allogeneic haematopoietic cell transplantation). An enzyme derived from viruses that infect these bacteria demonstrates potential for eradication therapy. A previously unknown enzyme can kill the bacteria that cause graft-versus-host disease in the treatment of blood disorders.

Nature
Openalex Percentile: Top 83%
Bacteriophages and microbial interactions
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A virus-derived enzyme can destroy the membrane structures that protect bacteria · Nature (2024) | TGRS Research Map | TGRS