Deletion of TP signaling in macrophages delays liver repair following APAP-induced liver injury by reducing accumulation of reparative macrophage and production of HGF
Deletion of TP signaling in macrophages delays liver repair following APAP-induced liver injury, which is associated with reduced accumulation of reparative macrophages and the hepatotrophic factor HGF. Specific activation of TP signaling in macrophages may be a potential therapeutic target for liver repair and regeneration after APAP hepatotoxicity.
Authors
- Hideki Amano (ORCID: https://orcid.org/0000-0001-5014-3462)
- Mina Tanabe
- Shuh Narumiya (ORCID: https://orcid.org/0000-0001-8062-6529)
- Yoshiya Ito (ORCID: https://orcid.org/0000-0001-5258-2098)
- Atsushi Yamashita (ORCID: https://orcid.org/0000-0002-1892-117X)
- Chika Kusano (ORCID: https://orcid.org/0000-0002-3789-4787)
- Masataka Majima (ORCID: https://orcid.org/0000-0003-2369-5610)
- Kanako Hosono
Institutions
- Kanagawa Institute of Technology (JP)
- Kyoto University (JP)
- Kitasato University (JP)
Publication Details
- Journal
- Inflammation and Regeneration
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1186/s41232-024-00356-z
- Citations
- 5
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.93