Phase II Trial of Gemcitabine and Nab-Paclitaxel for Recurrent Osteosarcoma with Serial Monitoring Using Liquid Biopsy: A Report from the National Pediatric Cancer Foundation
Gemcitabine and nab-paclitaxel demonstrated similar clinical activity and toxicity compared to previous retrospective reports utilizing gemcitabine and docetaxel in patients with recurrent osteosarcoma. Serial analysis of CTC and ctDNA was feasible in this prospective multi-institution study and provides preliminary data on the use of these assays in patients with relapsed disease.
Authors
- Jonathan Metts (ORCID: https://orcid.org/0000-0003-1068-7857)
- Brooke L. Fridley (ORCID: https://orcid.org/0000-0001-7739-7956)
- Daniel L. Adams (ORCID: https://orcid.org/0000-0002-1916-9637)
- Eric Sandler (ORCID: https://orcid.org/0000-0002-0083-9370)
- Emi Caywood (ORCID: https://orcid.org/0000-0002-2873-6058)
- Michael S. Isakoff (ORCID: https://orcid.org/0000-0003-4790-9919)
- Damon R. Reed (ORCID: https://orcid.org/0000-0002-8238-2465)
- Aditi Dhir (ORCID: https://orcid.org/0000-0001-9974-0073)
- David M. Loeb (ORCID: https://orcid.org/0000-0002-7319-5000)
- Masanori Hayashi (ORCID: https://orcid.org/0000-0002-9508-0159)
- Joanne Lagmay
- Lars M. Wagner (ORCID: https://orcid.org/0000-0003-4717-9960)
- Avery Bodlak (ORCID: https://orcid.org/0000-0001-9207-1532)
- Javier Oesterheld (ORCID: https://orcid.org/0000-0003-2035-8977)
- Leo Mascarenhas (ORCID: https://orcid.org/0000-0001-7790-0777)
- Christine A. Pratilas (ORCID: https://orcid.org/0000-0002-7116-0605)
- Scott C. Borinstein (ORCID: https://orcid.org/0000-0002-1721-1520)
- José Laborde (ORCID: https://orcid.org/0000-0002-2003-9653)
- Bhuvana A. Setty (ORCID: https://orcid.org/0000-0002-6054-817X)
- Hong Yin (ORCID: https://orcid.org/0000-0002-8184-113X)
- Jun Yin (ORCID: https://orcid.org/0000-0003-3242-9664)
- Matteo Trucco
Institutions
- Cedars-Sinai Medical Center (US)
- Albert Einstein College of Medicine (US)
- Nationwide Children's Hospital (US)
- Cleveland Clinic (US)
- Children's Mercy Hospital (US)
- UF Health Shands Hospital (US)
- Johns Hopkins University (US)
- University of Miami (US)
- Duke University (US)
- Moffitt Cancer Center (US)
- Children's Hospital Colorado (US)
- Johns Hopkins All Children's Hospital (US)
- Connecticut Children's Medical Center (US)
- Nemours Children's Health System (US)
- Center for Cancer and Blood Disorders (US)
- Creatv MicroTech (United States) (US)
- Levine Children's Hospital (US)
- Children's Healthcare of Atlanta (US)
- Nemours Children's Clinic (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Vanderbilt University Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1339
- Citations
- 9
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.77