p38α kinase governs muscle strength through <scp>PGC1α</scp> in mice
This knowledge holds relevance for conditions associated with muscle weakness, where disruptions in these molecular pathways are frequently implicated in diminishing physical strength. Our research underscores the potential importance of targeting the p38α and PGC1α pathways within muscle, offering promising avenues for the advancement of innovative treatments. Such interventions hold the potential to improve the quality of life for individuals affected by muscle-related diseases.
Authors
- Juan Antonio López (ORCID: https://orcid.org/0000-0002-9097-6060)
- Alfonso Mora (ORCID: https://orcid.org/0000-0002-6397-4836)
- Bruce M. Spiegelman (ORCID: https://orcid.org/0000-0002-7658-4802)
- Marta León (ORCID: https://orcid.org/0000-0003-4345-745X)
- Leticia Herrera‐Melle (ORCID: https://orcid.org/0000-0002-9630-2219)
- Cintia Folgueira (ORCID: https://orcid.org/0000-0003-3803-9149)
- Beatriz Cicuéndez (ORCID: https://orcid.org/0000-0002-5810-5185)
- Guadalupe Sabio (ORCID: https://orcid.org/0000-0002-2822-0625)
- Elena M. Rodríguez Rodríguez (ORCID: https://orcid.org/0000-0003-3807-4593)
- Ainoa Caballero
- Phillip A. Dumesic (ORCID: https://orcid.org/0000-0002-5843-2864)
- Jesús Vázquez (ORCID: https://orcid.org/0000-0003-1461-5092)
- Luis Leiva‐Vega (ORCID: https://orcid.org/0000-0002-0050-8117)
- Sarah E. Wilensky
Institutions
- Harvard University (US)
- Spanish National Centre for Cardiovascular Research (ES)
- Spanish National Cancer Research Centre (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Centro Nacional de Epidemiología (ES)
- Dana-Farber Cancer Institute (US)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1111/apha.14234
- Citations
- 3
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Eli Lilly and Company
- Georgia Southern University
- Fundación BBVA
- Fundación SEEN
- Comunidad de Madrid
- Society for Endocrinology
- European Foundation for the Study of Diabetes
- Universität Wien
- Ministerio de Educación, Cultura y Deporte
- Novo Nordisk
- Ministerio de Ciencia e Innovación
- Banco Bilbao Vizcaya Argentaria
- Medizinische Universität Wien
- Centro Nacional de Investigaciones Cardiovasculares
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación
- Centro Nacional de Biotecnología