Osteogenic effect of alogliptin in chemical-induced bone loss: a tri-modal <i>in silico</i>, <i>in vitro,</i> and <i>in vivo</i> analysis
Alogliptin increased mineralization in osteoblast cells. It had beneficial effects also altered bone turnover markers, repaired the trabecular microstructure, improved bone mineral density, and exhibited bone forming capacity targeting DPP-4 enzyme in postmenopausal osteoporosis.
Authors
- Mohammad Mumtaz Alam (ORCID: https://orcid.org/0000-0001-6420-8757)
- Mohammad Shaquiquzzaman (ORCID: https://orcid.org/0000-0002-3801-2782)
- Mohammad Ahmed Khan (ORCID: https://orcid.org/0000-0002-7401-3299)
- Divya Vohora (ORCID: https://orcid.org/0000-0003-1852-9191)
- Abul Kalam Najmi (ORCID: https://orcid.org/0000-0002-9299-414X)
- Anuja Krishnan (ORCID: https://orcid.org/0000-0001-6538-2044)
- Mohammad Altamish
- Syed Sufian Ahmad (ORCID: https://orcid.org/0000-0003-1800-2488)
- Faraha Ahmed
Institutions
- Jamia Hamdard (IN)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1093/jpp/rgae112
- Citations
- 3
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.70