Notch4 regulatory T cells and SARS‐CoV‐2 viremia shape COVID19 survival outcome

The clinical trajectory and survival outcome in hospitalized patients with COVID-19 is predicated on two cardinal factors in disease pathogenesis: viremia and Notch4<sup>+</sup> Treg cells. Intervention strategies aimed at resetting the immune dysregulation in COVID-19 by antagonizing Notch4 and pyroptosis may be effective in severe cases of viral lung infection.

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Publication Details

Journal
Allergy
Published
2024-10-03
DOI
https://doi.org/10.1111/all.16333
Citations
2
Primary Topic
Immune responses and vaccinations
Type
article
Field-Weighted Citation Impact
0.48

Funders

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article

Notch4 regulatory T cells and SARS‐CoV‐2 viremia shape COVID19 survival outcome

Claudia Angelini, Marcia B. Goldberg, Elena Crestani, Raffaele De Palma et al.
2 citations
Allergy
Immune responses and vaccinations
0.48
article

Notch4 regulatory T cells and SARS‐CoV‐2 viremia shape COVID19 survival outcome

Claudia Angelini, Marcia B. Goldberg, Elena Crestani, Raffaele De Palma, Hui‐Yu Sui, Ching‐Ying Huang, Hani Harb, Wanda Phipatanakul, Paola Contini, Luca Marri, Mehdi Benamar, Qian Chen, Andrea Guastalla, Talal A. Chatila, Jason Fong, Lorenzo Berra, Peggy S. Lai, Fatma Betül Öktelik, Daniel Okin, Muyun Wang, Merve Nida Gokbak, Minsik Kim, Chiara Vassallo, Tsz Man Chan Fion
article en
2 citations

Abstract

The clinical trajectory and survival outcome in hospitalized patients with COVID-19 is predicated on two cardinal factors in disease pathogenesis: viremia and Notch4<sup>+</sup> Treg cells. Intervention strategies aimed at resetting the immune dysregulation in COVID-19 by antagonizing Notch4 and pyroptosis may be effective in severe cases of viral lung infection.

AllergyVol. 80(2)
Boston Children's Hospital (US), Harvard University (US), Massachusetts General Hospital (US), Istituto per le Applicazioni del Calcolo Mauro Picone (IT), Institute of Protein Biochemistry (IT), Ospedale Policlinico San Martino (IT), University of Genoa (IT)
Boston Children's Hospital, Deutsche Gesellschaft für Suchtforschung und Suchttherapie, National Institutes of Health
Openalex Percentile: Top 34%
Immune responses and vaccinations
0.48
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