Notch4 regulatory T cells and SARS‐CoV‐2 viremia shape COVID19 survival outcome
The clinical trajectory and survival outcome in hospitalized patients with COVID-19 is predicated on two cardinal factors in disease pathogenesis: viremia and Notch4<sup>+</sup> Treg cells. Intervention strategies aimed at resetting the immune dysregulation in COVID-19 by antagonizing Notch4 and pyroptosis may be effective in severe cases of viral lung infection.
Authors
- Claudia Angelini (ORCID: https://orcid.org/0000-0001-8350-8464)
- Marcia B. Goldberg (ORCID: https://orcid.org/0000-0003-4266-9733)
- Elena Crestani (ORCID: https://orcid.org/0000-0001-7718-0431)
- Raffaele De Palma (ORCID: https://orcid.org/0000-0001-9070-8878)
- Hui‐Yu Sui
- Ching‐Ying Huang (ORCID: https://orcid.org/0009-0006-9890-4789)
- Hani Harb (ORCID: https://orcid.org/0000-0001-8218-2538)
- Wanda Phipatanakul (ORCID: https://orcid.org/0000-0001-8639-0473)
- Paola Contini (ORCID: https://orcid.org/0000-0001-9430-1928)
- Luca Marri (ORCID: https://orcid.org/0000-0003-0614-2950)
- Mehdi Benamar (ORCID: https://orcid.org/0000-0003-1532-8642)
- Qian Chen (ORCID: https://orcid.org/0000-0002-7771-2802)
- Andrea Guastalla
- Talal A. Chatila (ORCID: https://orcid.org/0000-0001-7439-2762)
- Jason Fong (ORCID: https://orcid.org/0000-0001-6164-6110)
- Lorenzo Berra (ORCID: https://orcid.org/0000-0003-2702-2093)
- Peggy S. Lai (ORCID: https://orcid.org/0000-0001-9501-8606)
- Fatma Betül Öktelik (ORCID: https://orcid.org/0000-0002-7994-5618)
- Daniel Okin (ORCID: https://orcid.org/0000-0002-3802-4695)
- Muyun Wang (ORCID: https://orcid.org/0009-0002-8422-0723)
- Merve Nida Gokbak (ORCID: https://orcid.org/0000-0002-9220-9455)
- Minsik Kim (ORCID: https://orcid.org/0000-0003-1095-840X)
- Chiara Vassallo (ORCID: https://orcid.org/0000-0001-8723-9863)
- Tsz Man Chan Fion
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Istituto per le Applicazioni del Calcolo Mauro Picone (IT)
- Institute of Protein Biochemistry (IT)
- Ospedale Policlinico San Martino (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Allergy
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1111/all.16333
- Citations
- 2
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- Boston Children's Hospital
- Deutsche Gesellschaft für Suchtforschung und Suchttherapie
- National Institutes of Health