Association between family history with lung cancer incidence and mortality risk in the <scp>Asia Cohort Consortium</scp>

Family history of lung cancer (FHLC) has been widely studied but most prospective cohort studies have primarily been conducted in non-Asian countries. We assessed the association between FHLC with risk of lung cancer (LC) incidence and mortality in a population of East Asian individuals. A total of 478,354 participants from 11 population-based cohorts in the Asia Cohort Consortium were included. A Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). A total of 7,785 LC incident cases were identified. FHLC (any LC subtype) was associated with an increased risk of LC incidence (HR = 1.45, 95% CI = 1.30-1.63). The positive association was observed in men and women (HR = 1.44, 95% CI = 1.26-1.66 in men; HR = 1.47, 95% CI = 1.22-1.79 in women), and in both never-smokers and ever-smokers (HR = 1.43, 95% CI = 1.18-1.73 in never-smokers; HR = 1.46, 95% CI =1.27-1.67 in ever-smokers). FHLC was associated with an increased risk of lung adenocarcinoma (HR = 1.63, 95% CI: 1.36-1. 94), squamous cell carcinoma (HR = 1.88, 95% CI: 1.46-2.44), and other non-small cell LC (HR = 1.94, 95% CI: 1.02-3.68). However, we found no evidence of significant effect modification by sex, smoking status, and ethnic groups. In conclusion, FHLC was associated with increased risk of LC incidence and mortality, and the associations remained consistent regardless of sex, smoking status and ethnic groups among the East Asian population.

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Journal
International Journal of Cancer
Published
2024-10-03
DOI
https://doi.org/10.1002/ijc.35191
Citations
4
Primary Topic
Global Cancer Incidence and Screening
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article
Field-Weighted Citation Impact
1.13
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article

Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium

Eiko Saito, Xin Yin, Habibul Ahsan, Wei Jie Seow et al.
4 citations
International Journal of Cancer
Global Cancer Incidence and Screening
1.13
article

Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium

Eiko Saito, Xin Yin, Habibul Ahsan, Wei Jie Seow, Sun‐Seog Kweon, Seiki Kanemura, Md. Shafiur Rahman, Paolo Boffetta, You‐Lin Qiao, Batel Blechter, Nathaniel Rothman, Jeongseon Kim, Daehee Kang, Akiko Tamakoshi, Sarah Krull Abe, Md. Rashedul Islam, Keitaro Matsuo, Norie Sawada, Yumi Sugawara, Kee Seng Chia, Manami Inoue, Xiao‐Ou Shu, Sue K. Park, Rie Kishida, Wei Zheng, Atsushi Hozawa, Qing Lan
article en
4 citations

Abstract

Family history of lung cancer (FHLC) has been widely studied but most prospective cohort studies have primarily been conducted in non-Asian countries. We assessed the association between FHLC with risk of lung cancer (LC) incidence and mortality in a population of East Asian individuals. A total of 478,354 participants from 11 population-based cohorts in the Asia Cohort Consortium were included. A Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). A total of 7,785 LC incident cases were identified. FHLC (any LC subtype) was associated with an increased risk of LC incidence (HR = 1.45, 95% CI = 1.30-1.63). The positive association was observed in men and women (HR = 1.44, 95% CI = 1.26-1.66 in men; HR = 1.47, 95% CI = 1.22-1.79 in women), and in both never-smokers and ever-smokers (HR = 1.43, 95% CI = 1.18-1.73 in never-smokers; HR = 1.46, 95% CI =1.27-1.67 in ever-smokers). FHLC was associated with an increased risk of lung adenocarcinoma (HR = 1.63, 95% CI: 1.36-1. 94), squamous cell carcinoma (HR = 1.88, 95% CI: 1.46-2.44), and other non-small cell LC (HR = 1.94, 95% CI: 1.02-3.68). However, we found no evidence of significant effect modification by sex, smoking status, and ethnic groups. In conclusion, FHLC was associated with increased risk of LC incidence and mortality, and the associations remained consistent regardless of sex, smoking status and ethnic groups among the East Asian population.

International Journal of CancerVol. 156(4)
Chonnam National University (KR), Hitotsubashi University (JP), Seoul National University (KR), University of Tsukuba (JP), National University of Singapore (SG), Chicago Department of Public Health (US), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Tohoku University (JP), Hokkaido University (JP), Hamamatsu University School of Medicine (JP), University of Chicago (US), National Cancer Center (KR), Aichi Cancer Center (JP), National Cancer Institute (US), National University Health System (SG), Hokkaido Institute of Public Health (JP), Division of Cancer Epidemiology and Genetics, Stony Brook University (US), Nagoya University (JP), The University of Tokyo (JP), Vanderbilt University Medical Center (US), University of Bologna (IT)
Good health and well-being
Openalex Percentile: Top 18%
Global Cancer Incidence and Screening
1.13
DOIOpen Access PDFOpenAlex
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