Lipid peroxidation triggered by the degradation of xCT contributes to gasdermin D-mediated pyroptosis in COPD
The results of this study suggested that the ubiquitination-mediated degradation of xCT drives GSDMD-mediated pyroptosis in COPD and is a potential therapeutic target for COPD.
Authors
- Laiyu Zhu
- Tianhua Hou
- Shucheng Hua (ORCID: https://orcid.org/0000-0002-0083-3542)
- Xinxin Ci (ORCID: https://orcid.org/0000-0003-2207-6869)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-0472-3399)
- Ying Tang (ORCID: https://orcid.org/0000-0002-1582-645X)
- Liping Peng (ORCID: https://orcid.org/0000-0002-3499-4037)
- Yun Gao
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1016/j.redox.2024.103388
- Citations
- 21
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.91