Large scale analysis of the SARS-CoV-2 main protease reveals marginal presence of nirmatrelvir-resistant SARS-CoV-2 Omicron mutants in Ontario, Canada, December 2021–September 2023
The observations suggest that, as of September 2023, no significant or widespread resistance to nirmatrelvir has developed among SARS-CoV-2 Omicron variants in Ontario. This study highlights the importance of creating automated monitoring systems to track the emergence of nirmatrelvir-resistant mutations within the SARS-CoV-2 virus, utilizing genomic data generated in real-time.
Authors
- Sandra Isabel (ORCID: https://orcid.org/0000-0001-7277-4150)
- Kirby Cronin (ORCID: https://orcid.org/0000-0002-5124-3446)
- Jonathan B. Gubbay (ORCID: https://orcid.org/0000-0003-0026-3786)
- Fatima Shire
- Thomas Braukmann (ORCID: https://orcid.org/0000-0002-2452-3776)
- Venkata R. Duvvuri (ORCID: https://orcid.org/0000-0001-7356-338X)
- Alex Marchand‐Austin (ORCID: https://orcid.org/0000-0001-5932-2037)
- Karthikeyan Sivaraman
- Julianne V. Kus (ORCID: https://orcid.org/0000-0001-6033-7244)
- Antoine Corbeil (ORCID: https://orcid.org/0000-0003-1983-1974)
- Hadia Hussain (ORCID: https://orcid.org/0000-0001-7034-6574)
- Shawn T. Clark (ORCID: https://orcid.org/0000-0002-7160-304X)
- Alireza Eshaghi (ORCID: https://orcid.org/0000-0001-5150-483X)
- Maan Hasso (ORCID: https://orcid.org/0000-0002-4608-8883)
- Austin Zygmunt (ORCID: https://orcid.org/0000-0002-4219-6887)
- Ye Li (ORCID: https://orcid.org/0000-0001-7727-0875)
- Aimin Li (ORCID: https://orcid.org/0000-0001-9459-5540)
- Samir N. Patel (ORCID: https://orcid.org/0000-0001-9824-7623)
- Ashleigh Sullivan (ORCID: https://orcid.org/0000-0002-7040-2414)
- Hina Bandukwala
- Nobish Varghese
- Karam Ramotar
Institutions
- 3M (United States) (US)
- University of Ottawa (CA)
- University of Toronto (CA)
- Public Health Ontario (CA)
Publication Details
- Journal
- Canada Communicable Disease Report
- Published
- 2024-10-03
- DOI
- https://doi.org/10.14745/ccdr.v50i10a05
- Citations
- 4
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.56