In(OTf)3-catalyzed one-pot synthesis of α-amido arylketazines

• One-pot In(OTf) 3 -catalyzed synthesis of diversified α-amido arylketazines. • Hydrazine-mediated double condensation of α-ketoamides. • Key products could be confirmed by X-ray crystallography. • One-pot process for the formations of two carbon-nitrogen double (C N) bonds. The one-pot synthesis of diversified α-amido arylketazines was developed under the oxygen atmosphere conditions. In(OTf) 3 -catalyzed benzylic oxidation of various α-arylacetamides followed by hydrazine (N 2 H 4 ·2HCl)-mediated double condensation of the resulting α-ketoamides through the formation of two carbon-nitrogen double (C N) bonds. A plausible mechanism is proposed and well-discussed. The one-pot synthesis of diversified α-amido ketazines is developed by one-pot In(OTf) 3 -catalyzed benzylic oxidation of various arylacetamides followed by hydrazine-mediated double condensation of the resulting α-ketoamides.