Panel of serum biomarkers for differential diagnosis of idiopathic interstitial lung disease and interstitial lung disease-secondary to systemic autoimmune rheumatic disease
Our study showed the excellent diagnostic value of KL-6 for detecting ILD, which irrespective of the final diagnosis and extent of disease, is always elevated and is a reliable biomarker of lung fibrosis in various diseases, ranging from idiopathic to autoimmune forms. Our study proposed an ILD differentiation model including clinical background. In this context, combination of serum markers and clinical data, as seen in our cohort, may lead to a further improvement in diagnostic accuracy for ILD.
Authors
- Miriana d’Alessandro (ORCID: https://orcid.org/0000-0002-2368-5722)
- Sara Gangi (ORCID: https://orcid.org/0000-0003-1834-535X)
- Paolo Cameli (ORCID: https://orcid.org/0000-0001-8639-2882)
- Bruno Frediani (ORCID: https://orcid.org/0000-0001-6003-7567)
- Laura Bergantini (ORCID: https://orcid.org/0000-0002-1118-3223)
- Elena Bargagli (ORCID: https://orcid.org/0000-0002-8351-3703)
- Lisa Spencer (ORCID: https://orcid.org/0000-0003-3558-992X)
- Edoardo Conticini (ORCID: https://orcid.org/0000-0002-3974-6606)
- Hector Chinoy (ORCID: https://orcid.org/0000-0001-6492-1288)
- Janine A. Lamb (ORCID: https://orcid.org/0000-0002-7248-0539)
- Robert P New
- Caroline Cotton
- Sarah Sugden
Institutions
- University of Siena (IT)
- University of Liverpool (GB)
- Aintree University Hospitals NHS Foundation Trust (GB)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- Aintree University Hospital (GB)
- Salford Royal Hospital (GB)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1371/journal.pone.0311357
- Citations
- 4
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 1.68