Age, anticoagulants, hypertension and cardiovascular genetic traits predict cranial ischaemic complications in patients with giant cell arteritis
Age and hypertension were risk factors for cranial ischaemic complications at GCA presentation, but in this dataset, anticoagulation appeared protective. Positional gene mapping suggested a role for immune and coagulation-related pathways in the pathogenesis of complications. Further studies are needed before implementation in clinical practice.
Authors
- Natalie Chaddock (ORCID: https://orcid.org/0000-0002-2256-5278)
- Ann W Morgan (ORCID: https://orcid.org/0000-0003-1109-624X)
- E. O'Sullivan (ORCID: https://orcid.org/0000-0003-0099-3551)
- Mark M. Iles (ORCID: https://orcid.org/0000-0002-2603-6509)
- Charlotte J. Harden (ORCID: https://orcid.org/0000-0002-1897-2364)
- Susan P. Mollan (ORCID: https://orcid.org/0000-0002-6314-4437)
- Hannah R. Mathieson (ORCID: https://orcid.org/0000-0002-0282-2708)
- Javier Martı́n (ORCID: https://orcid.org/0000-0002-2202-0622)
- Michal Zulcinski (ORCID: https://orcid.org/0000-0003-4570-1882)
- Catherine Lawson (ORCID: https://orcid.org/0000-0003-3156-598X)
- Sarah Mackie (ORCID: https://orcid.org/0000-0003-2483-5873)
- Louise Sørensen
Institutions
- University of Leeds (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- NIHR Leeds In Vitro Diagnostics Co-operative (GB)
- Harrogate District Hospital (GB)
- NIHR Surgical Reconstruction and Microbiology Research Centre (GB)
- King's College Hospital (GB)
- Instituto de Parasitología y Biomedicina "López - Neyra" (ES)
- University of Birmingham (GB)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1136/ard-2024-225515
- Citations
- 5
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Leeds Hospital Charitable Foundation
- National Institute for Health and Care Research
- European Commission
- Medical Research Council
- Leeds Biomedical Research Centre